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Initial metabolomics investigations unveiled a noteworthy correlation between urinary MNAM levels and BMI (Salek et al., 2007

When pooling five RCTs of vitamin D (from Iran, Europe, and Asia), we found a moderate overall effect (pooled SMD ~0.5 on symptom scales) favoring supplementation and a relative risk of ~1.6 for achieving a clinically significant improvement versus placebo

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At physiological or moderately elevated doses, pyridoxine is generally well tolerated, and side effects tend to be mild