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Notably, lignans exhibit anti-cancer activity through multiple regulatory pathways ( 3 Factors affecting the appropriate extraction methods for phenolic compounds Polyphenols comprise a broad array of chemical structures, resulting in varied chemical and physical properties ( Furthermore, extraction efficiency is highly sensitive to operational parameters such as pH, type of solvent employed, solvent-to-sample ratio, and duration of the extraction process (34)

In mammalian cells, ER stress leads to an integrated stress response involving the related transmembrane kinases Ire1, Ire1 and PKRlike ER kinase (PERK), and the transmembrane activating transcription factor 6 (ATF6) (Zhang & Kaufman, 2004)

Thus, the glyoxalase system in trypanosomes is a potential drug target (Silva et al., 2008, Wyllie and Fairlamb, 2011, Manta et al., 2013)

After muscle injury, tissue-resident macrophages migrate to the injured area, and part of them prevents complete monocytes recruitment from the circulation [59]

RNA density was measured using NanoDrop ND-1000 Spectrophotometer (NanoDrop Technologies, Wilmington, DE, USA)