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To further elucidate the physiological significance of DLPs in bacterial clearance by macrophages, we established in vivo model of macrophage re-infusion during bacterial infection

doi: 10.1158/0008-5472.CAN-10-1418

Several animal studies indicate that MPs reduce gut microbial diversity and shift the dominant phylum ratioparticularly elevating the Firmicutes-to-Bacteroidetes (F/B) ratiowhile depleting beneficial genera like Bifidobacterium and enriching opportunistic pathogens like Staphylococcus 31,36,77

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The study included over 6,800 men and women who were 45 to 84 years of age