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B12 is important for making healthy red blood cells

For the most part, that guidance holds up

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Kidney injury appears only as a secondary effect of dehydration from severe gut upset. Anti-drug antibodies form in roughly half to two-thirds of users but do not affect clearance, weight, or blood sugar. Benefits that look like side effects Tirzepatide lowers uric acid (about -0.7 to -1.0 mg/dL, mostly through weight loss) and lowers blood pressure

Restoring normal B12 levels helps your body produce adequate red blood cells and supports healthy nerve function, both of which are vital for feeling energetic and mentally well