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Cosmetically active compounds (CACs), both of lipophilic and hydrophilic origin, have difficulty reaching the deeper layers of the skin, and this shortcoming significantly reduces their efficacy

doi:10.1016/s0735-1097(97)00005-3 129 Niemi, T

Nrf2 activation inhibits NFB pathway mainly by elevating HO1 expression and antioxidant defenses which neutralize ROS and detoxifying chemicals.118 It also controls NFB pathway through Keap1, which stabilizes the NFB inhibitor (IKB) and represses degradation of NFB kinase inhibitor (IKK), leading negatively to the regulation of NFB pathway.119 NFB exerts its negative effect on Nrf2driven gene expression through p65, along with MafK and histone deacetylase3 (HDAC3)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Sun L., Wu Q., Mao X