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10.1074/jbc.271.35.21309 10 Avidor-ReissT.NevoI.SayaD.BayewitchM.VogelZ

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In phase I, enzymes such as cytochrome P450 monooxygenase (P450s) and carboxylesterase act directly on the toxin molecule, catalyzing the oxidation, reduction, and chemical cleavage of toxins, thereby increasing the reactivity and hydrophilicity of the toxin 11,12

Rational conversion of chromophore selectivity of cyanobacteriochromes to accept mammalian intrinsic biliverdin
