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Next, cysteine combines with glutamate and glycine to form glutathione

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In mouse models, boosting NAD+ has been shown to reverse DNA damage, reduce mutation load, and extend lifespan in progeroid models of aging

Thiol donors and analogues (GSH and mucolytic medications, such as N-acetyl-L-cysteine, nacystelyn, erdosteine, and carbocysteine lysine salt), dietary polyphenols, and flavonoids (curcumin, resveratrol, green tea-catechins, quercetin) have all been shown to scavenge and detoxify free radicals and oxidants, raise intracellular thiol levels, regulate NF-\( \kappa \) activation, and ultimately suppress the expression of inflammatory genes [102] (Table 3)

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