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In contrast, when PKM2 exists in its monomeric or dimeric form, it can enter the nucleus and function as a coactivator for several transcription factors (such as HIF-1, -catenin/c-Myc, NF-B, and STAT3), regulating metabolic reprogramming and gene expression to meet various physiological demands [49]

These investigations are conducted strictly within controlled laboratory environments to support structured analysis of peptide-driven signaling activity, receptor interaction dynamics, and downstream pathway modulation under defined experimental conditions

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