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BioMed research international, 2015(1), 648108

Blockage of Bcl-XL function by PUMA- gives way to Bax and Bak to change their conformation and form pores in the outer mitochondrial membrane, leading to the cytochrome c release into cytosol, apoptosome formation, subsequent caspase activation, and following apoptosis [33, 34]

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Overall, this data suggests that the importin :Ran-GDP:RanBP1 complex is not directly involved in mediating the nuclear import of NLS cargos through the NPC

Diabetologia 46 , 394400 (2003)