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Figure 4: Effects of Intrinsic Factors on Aripiprazole Pharmacokinetics Figure 5: Effects of Intrinsic Factors on Dehydro-aripiprazole Pharmacokinetics Animal Toxicology And/Or Pharmacology Intramuscular administration of aripiprazole lauroxil to rats and dogs was associated with injection site tissue reactions at all doses in rats treated up to 6 months at doses of 15, 29, and 103 mg/animal (which are approximately 0.3 to 2 times and 0.5 to 3 times the MRHD of 1064 mg on mg/m basis in males and females, respectively) and in dogs treated up to 9 months at doses of 147, 662, and 2058 mg/animal (which are approximately 0.5 to 6 times and 0.6 to 8 times the MRHD in males and females, respectively on mg/m basis)

[DOI] [PubMed] [Google Scholar] 35.Morris D., Guerra C., Donohue C., Oh H., Khurasany M., Venketaraman V

[PMC free article: PMC1642707] [PubMed: 16815800] 113

In fact, glutathione may help support liver function during hormone metabolism

Clinical Benefits Supports NAD+ metabolism and mitochondrial functionkey factors in cellular energy production, vitality, and overall metabolic efficiency