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Blockade of the Activin Receptor IIB activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism

Preclinically, these inhibitors reduce infarct volumes and improve functional recovery, not merely by lowering lactate but by reprogramming cellular metabolism: forcing neurons to resurrect oxidative phosphorylation in salvageable penumbral regions and redirecting glucose toward the PPP to bolster NADPH-dependent antioxidant defenses [208, 209]

10.1016/j.bbabio.2015.04.009 Biochim

It has been hypothesized - but never convincingly proven - that some other patients may have microscopic damage to the bladder wall

doi: 10.1681/ASN.2015080907