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Description
PMID: 15385313
Homologous recombination is traditionally used to create knockout mice, but it can also be used to knock in a transgene
Moreover, Mn overload contributes to various forms of toxicity through several mechanisms
It stimulates the production of several downstream antioxidants, anti-inflammatory proteins, and detoxification enzymes by triggering the Kelch-like ECH-associating protein 1 (Keap1)-Nrf2-antioxidant response element (ARE) signaling pathway
Ai Zheng
