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While some immune functions (DNA synthesis) are favored by high GSH levels, certain signal pathways are enhanced by oxidative conditions and lower intracellular glutathione concentrations, indicating that GSH operates as a bidirectional immunomodulator rather than a simple immunostimulant

Similarly, after treatment with azelaic acid, the expression of KLK-5 and cathelicidin mRNA, factors associated with major rosacea pathophysiologic pathways as previously described, decreased in patients with rosacea as well [141]

(6) Complex I in the regulation of ferroptosis Complex I: a context-dependent regulator of ferroptosis Complex I (NADH:ubiquinone oxidoreductase), the primary entry point of electrons into the mitochondrial ETC, has been implicated in ferroptosis regulation through its involvement in maintaining the redox state of CoQ 10

doi: 10.1073/pnas.89.6.2394