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Currently, several clinical trials are evaluating PARP-1 inhibitors for the treatment of acute ischemic stroke, ischemic acute kidney injury, myocardial ischemia, diabetes and related cardiovascular complications, shock, and traumatic central nervous system injuries [e.g., JPI-289, Phase 2, NCT03062397 [88, 103]

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Am J Clin Nutr 1991

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A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease

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Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (Sn-butyl homocysteine sulfoximine)

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Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development

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