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At the onset, environmental triggers including infections (e.g., streptococcal pharyngitis), trauma (Koebner phenomenon), psychological stress, smoking, or medications activate APCs such as dendritic cells and macrophages within the dermis (Hugh and Weinberg 2018

Patients with personal or family history of pancreatitis, gallstones, or severe kidney disease require careful provider assessment before starting tirzepatide

It has been declared, that neurotoxic 6-hydroxydopamine (and also superoxide radical) is able to release free iron from ferritin which in turn may participate in Fenton chemistry, forming ROS and initiating lipid peroxidation (Monteiro and Winterbourn 1989)

The DLM toxicity triggered a severe lymphocytic infiltration with dispersed melanomacrophages (Figure 9C)
