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This study was partially supported by the National Key R&D Program of China (No
10.4049/jimmunol.1602073 68
To demonstrate the benefits of the alkaline wash step, 19 human monoclonal IgG 1 antibody clones (17 light chain, 2 light chain) were purified from 21 medium batches by the standard method or alkaline wash method with a pH 11.0 buffer
These studies have examined its stability in gastric acid and its systemic availability following different routes of administration in controlled laboratory settings
