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Because L--glutamyl-p-nitroanilide is disadvantageous for practical use in clinical chemistry testing due to its slight solubility, L--glutamyl-3-carboxy-4-nitroanilide, an alternatively modified substrate, is instead generally favored for easier handling in clinical examinations [85]

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If nonoperative treatment is not successful or in cases where there has been a traumatic event, surgical treatment may be considered

XDH is irreversibly converted to XO by proteolysis or reversibly converted by phosphorylation or oxidation of thiols

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