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HFD alters epigenetic modifying enzymes and their activities in the liver DNA methylation and demethylation are the important epigenetic markers of gene regulation

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Real-time PCR also showed enhanced expression of Sestrin2 ( Sesn2 ), which acts as a cellular stress sensor that detects changes in redox status and responds accordingly to maintain cellular homeostasis (Fig

These results suggest that compounds able to buffer GSH decrement could be promising candidate drugs to prevent or treat the onset and progression of inflammatory condition/diseases (i.e., aging, atrophy, cachexia, sarcopenia)