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TNF- has been shown, mainly in experimental ED models and chronic inflammatory or metabolic conditions, to activate caspase-dependent apoptotic pathways while inhibiting the PI3K/Akt survival pathway (134)
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[DOI] [PubMed] [Google Scholar] 130.Markowska AL, Ingram DK, Barnes CA, Spangler EL, Lemken VJ, Kametani H, Yee W, Olton DS
