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The translocated AIFM1MIF complex then translocates back to the nucleus, where it contributes to chromatin condensation and DNA fragmentation, ultimately resulting in parthanatos-mediated cell death [154]

For example, it was found that in rat mammary cells, the frequency of initiation (the first step in oncogenesis) induced by -rays was much higher than specific locus mutations [203,204,205], and that the observed frequency of radiation-induced GI is considerably higher than that observed for gene mutations at a similar dose, suggesting that the latter is highly unlikely to be the initiating mechanism for GI [145,146,188]

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