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In the liver, the HCV particles are brought into the hepatic sinusoids by blood flow

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Dermoscopically, these colors correspond to superficial structures, which correspond to the histopathologic condition of melanosis that is characterized by hyperpigmentation of basal keratinocytes

Non-Selective Multi-Receptor Action Pigmentation (MC1R): Activation of MC1R on melanocytes stimulates melanogenesis and the production of protective eumelanin, leading to skin darkening (tanning) without extensive UV exposure