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However, these treatments often rely on enema or oral administration, which generally suffers from limited rectal retention time, insufficient local drug exposure, or low systemic bioavailability, thus limiting efficacy stability and patient compliance [7, 9]

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Tesofensine, a triple monoamine reuptake inhibitor, works primarily in the brain to decrease appetite and potentially increase energy expenditure

has received speakers honoraria from Octapharma and Alexion and consulting honoraria from Argenx and Ra Pharma