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Gemcitabine plus cisplatin (GemCis) has been the first-line standard of care for advanced unresectable CCA, based on results from the ABC-02 trial showing median overall survival and progression-free survival of 11.7 and 8.0 months, respectively (Valle et al., 2010)

The pharmacokinetics may differ slightly

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30 Whereas IENF density and mtDNA copies/cell did not change after therapy, improvements in neuropathic pain, paresthesias, and symptoms of numbness were observed
