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There is also some evidence that N- acetylcysteine reduces mortality in paracetamol induced liver failure, although the drug acts via a different mechanism from glutathione repletion [813]

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PMCID: PMC4075452 Griffith O, Meister A (1979) Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)

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However, the expected increase in the SAM/SAH ratio in response to B12 was not observed