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Am J Physiol Gastrointest Liver Physiol (2014) 307:G397409

The change of brain microenvironment caused by acute cerebral I/R is the main obstacle to nerve function recovery, and a significant reason of stroke recurrence after thrombolytic therapy

On the other hand, also in the extracellular space, the cysteinyl-glycine fraction is split by the enzyme dipeptidase generating cysteine and glycine

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DSF/Cu has also demonstrated significant clinical potential in the treatment of NPC: it can induce ferroptosis in tumor cells through the ROS/MAPK-p53 pathway and promote apoptosis and necrosis of -SMA-positive cancer-associated fibroblasts (CAFs)