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What you eat shows up on your face
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
Only when Daughaday et al
However, their modest efficacy in slowing GA lesion growth without demonstrating clear functional benefit, the burden of monthly or bi-monthly intravitreal injections, and potential safety concerns, including an increased risk of conversion to neovascular AMD, have limited their clinical use and precluded regulatory approval in Europe
5-Amino-1MQ is the tool of choice for studies designed to reverse or mitigate these changes at a cellular level
