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Studies using lactulose (L) and mannitol (M), two sugar probes commonly used to evaluate small intestinal permeability in humans, have shown either no change or modestly increased permeability [212]

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Figure 11 The phosphinic group is, as compared to, e.g., thiols and hydroxamic acids more weakly binding to zinc ions in metalloproteases and a significantly improved selectivity could be achieved by systematic variations of the side chains at P1 and P2 positions of 43

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