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In addition, the ERGO-induced microglial M2 polarization may further suppress TDP43 aggregation since microglial activation is related to the aggregation, and M2 microglia especially are more efficient phagocytes for brain wastes than M1 microglia [35, 72, 73] TDP43 activates microglia through NF-B and NLRP3 inflammasome [70], and the impaired microglial phagocytosis of dying neurons may contribute to the formation of pathological TDP43 [74]