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Nevertheless, emerging data allow us to propose that severe hyperhomocysteinemia might primarily have homocysteinylation effects related to homocysteine and/or its by-products (as homocysteine thiolactone) that would affect the vascular wall structure through a mechanism independent of an oxidant stress

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[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Vitamin B12 intake from animal foods, biomarkers, and health aspects

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Treatment is generally limited to 812 weeks before cycling off to evaluate response

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