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In prostate cancer, delivery of modified PTEN mRNA via PEG-coated polymer-lipid hybrid NPs has demonstrated promising results in increasing tumor suppression potential, inducing apoptosis, inhibiting cell viability, and suppressing the PI3K pathway [350]

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Mitochondrial oxidative stress is the Achille's heel of melanoma cells resistant to Braf-mutant inhibitor
For 13 patients (10%) who were older than 70 years, a clinical regression of melanosis was observed
