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On the apical area in close contact with the intestinal lumen, enterocytes are linked by tight junctions and impaired intestinal permeability may result from an increase in zonula occludens proteins
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USA 106 , 37943799 (2009)
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This time-temperature relationship is why the FDA gives a specific number of days (21) at a specific maximum temperature (86 degrees Fahrenheit) rather than just a temperature limit
