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Curr Opin Cell Biol 24: 262268 Stern S, Kirst C, Bargmann CI (2017) Neuromodulatory control of longterm behavioral patterns and individuality across development

PMID: 19386128

LRSAM1 (leucine rich repeat and sterile alpha motif containing1), also called RIFLE and TAL (TSG101-associated ligase), is an E3 type ubiquitin ligase

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However, another study from Japan showed that the eradication effectiveness of first-line triple therapy with amoxicillin, clarithromycin, and vonoprazan decreased with age, possibly due to reduced gastric acid secretion in older patients, reducing the need for maintenance therapy with vonoprazan (Kusunoki et al., 2019)