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Notably, the hepsin / mice exhibited a more pronounced increase in ROS levels after thioacetamide treatment compared with wild-type mice, which aligned with our hypothesis that hepsin / mice experience heightened ROS stress in the early stages of APAP exposure due to their elevated expression of GJ proteins (Fig

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The SS possesses similar penetration ability, affinity towards IMM and proton gradientdriven mechanism These agents have been specifically utilized for inherent antioxidant effect, and various studies have supported their application as a drug delivery voyage system [45]