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The reason is because after the 2 nd round, there is often additional improvement noted

Cancer cell-DRG coculture system The cancer cell-DRG coculture system was performed according to the method described previously [13]

9 Approval of sorafenib (multi-kinase inhibitor of vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and Raf kinases) was the first systemic therapy to conclusively demonstrate an improvement in overall survival in patients with advanced HCC

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One day after injection, the amount of QMP in the plasma was twice that of WT albumin, a difference that increased to more than 4-fold on day 10 (Fig