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2019 Jan;85(2):216-224

Cell 47 , 422433 (2012)

Effect of intraoperative application of ketamine on postoperative depressed mood in patients undergoing elective orthopedic surgery

For instance, miR-7 and miR-153 have been implicated in the pathology of PD where they have been identified to specifically bind to 3-untranslated regions of -synuclein, connotating that overexpression of these miRNAs can cause a significant decrease in the protein and mRNA levels of -synuclein in patients with sporadic PD ( The biological effects of melatonin regarding PD are vastly widespread

For example, a high dose of N-acetylcysteine (1,200 mg/day) paradoxically increased oxidative damage in hypertensive patients, while 600 mg/day reduced MDA by 27% (Szkudlinska et al., 2016)