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This system tasked with defending the body from diseases and infections mistakenly attacks healthy cells, tissues, and organs weakening and even threatening the health and function of the affected body part

Neutrophil elastase inhibitor (sivelestat) attenuates subsequent ventilator-induced lung injury in mice

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Pyrogallol, another downstream metabolite, was found to enhance HO-1 expression in human umbilical cord mesenchymal stem cells (hUCMSCs), potentially strengthening their antioxidant and anti-inflammatory capabilities in an LPS-induced acute lung injury (ALI) model (Zhang et al., 2022), although direct suppression of inflammatory mediators was not explicitly demonstrated

Notably, Erastin-induced GSH depletion also promotes cardiolipin peroxidation, which not only triggers the opening of the mitochondrial permeability transition pore but also induces caspase-dependent and -independent apoptosis [218, 220222]