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however, this isn't directly linked to significant weight loss

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This localized reaction typically resolves within hours to a few days, but understanding what's normal versus what warrants provider contact is critical

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55 Although adiponectin does not seem to cross the blood-brain barrier, 56,57 the ARC 58 and the area postrema 59 respond to adiponectin, suggesting that these cells could be involved in relaying the signal to other brain regions