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Two key regulatory pathways (p16-CDK4-RB and ARF-MDM2-p53 pathway) are involved in controlling cells duplication activities from unrestrained progression of cell cycles, whereby the principal proteins involved in these distinct pathways are retinoblastoma tumor suppressor protein (RB) and p53 tumor suppressor protein (Fig

Gupta, M., Mahajan, V

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And many of the things that people are well aware of, higher levels of blood sugar, for example, infections can do it, inflammatory chemicals in the body, i.e., inflammation from anywhere in the body, i.e., leaky gut can relate back to the brain and change these important cells that make up about 10 to 15% of the brain cells that are involved in maintenance that can change these cells from being friend to foe