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Animal experiment also documented correlations of serum UA levels with lower striatal dopamine levels, tyrosine hydroxylase-positive neuronal death in the SN pars compacta, and the degree of oxidative stress in the midbrain

doi: 10.1083/jcb.202111095

Yan B, Yu X, Cai X, Huang X, Xie B, Lian D, et al

Similar content being viewed by others Introduction Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease, is an autosomal dominant cerebellar ataxia characterized by motor incoordination, progressive external ophthalmoplegia, progressive functional disabilities, and other neurological manifestations

It appears that some patients feel better and function better when they have higher levels (cellular and blood levels)
