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71 Interestingly, metabolite profiling of cells treated with Cu ionophore presents a time-dependent increase in the dysregulation of many TCA cycle-associated metabolites, and inhibiting the electron transport chain complexes I and II significantly reduced Cu-induced cell death

Conversely, HIF1 recruits RORt and p300 to the Il17a promoter, thereby transactivating Il17a expression and promoting Th17 cell differentiation

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Understanding who is at risk can help in taking proactive measures to prevent or address vitamin B12 deficiency