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There is every reason to argue that the efficacy observed for compounds 1 and 2 in vivo incorporates a similar role for the host immune response as seen for other schistosomicidal agents

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and site-specific inhibitors (S1QELs) can suppress this O 2 /H 2 O 2 output without affecting basal respiration, demonstrating that the site of generation dictates specific signaling outcomes [24, 72]

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321 Consequently, a deeper exploration of its mechanistic pathways and therapeutic potential is warranted, aiming to elucidate novel strategies and substantiate evidence for the prevention and management of these diseases