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One such gene is MALAT1, a long non-coding RNA located on chromosome 11q13.1 initially discovered in NSCLC, which also plays a regulatory role in vascular biology

Compared with Caucasian women with symptomatic myomas, women of African descent frequently present to their provider at a younger age and with a significantly worse myoma burden (larger size and number) and have a threefold higher risk of hysterectomy [4]

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Among the genes that were most significantly upregulated by AGXT overexpression were members of the cytochrome P450 CYP2 family such as Cyp2c37 , Cyp2c50 , Cyp2c54 and Cyp2e1 that regulate FAO and polyunsaturated fatty acid (PUFA) metabolism 37,38 and Cd163 , a known marker of anti-inflammatory macrophages 39