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Trimetazidine protects against smoking-induced left ventricular remodeling via attenuating oxidative stress, apoptosis, and inflammation

The recently described constitutional mismatch repair syndrome may also be associated with hypo or hyperpigmented lesions, but in the latter case, they appear to have more irregular and diffuse borders than typical CaLS.39 Despite the rarity of this syndrome, its possibility should not be ignored, as patients are at high risk of tumors in the intestines and central nervous system, as well as hematological cancers in the early years of life, and up to 97% of the 34 patients in follow-up in an international consortium study had at least one CaLS since childhood.39 Finally, other genodermatoses indicated in the table may be associated with CaLS,12 but there are usually too few of them to meet the diagnostic criterion for NF1

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These investigations primarily focus on understanding peptide-mediated signaling events associated with angiogenesis, cellular migration, cytoprotection, and extracellular matrix dynamics