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This suggests, as expected, an enhanced therapeutic window in case of the prodrug system

Neuroendocrine responses to saunas have primarily focused on stress-related hormones such as beta-endorphin and ACTH
10.1016/j.bbapap.2015.01.014 Biochim

the prefrontal cortex contains this microcircuit specialized for working memory [62]
[DOI] [PMC free article] [PubMed] [Google Scholar] [351].Grace PM, Tawfik VL, Svensson CI, Burton MD, Loggia ML, Hutchinson MR, The Neuroimmunology of Chronic Pain: From Rodents to Humans, The Journal of Neuroscience 41(5) (2021) 855865