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Institute of Medicine, 2016

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A change in carbon source, from glucose to lactate in minimum media, or exposure to hypoxic conditions also reduces the thickness of the inner layer by 50% (Ballou et al., Cell Wall Remodeling in Response to Lactate Despite the fact that the inner layer is covered by the outer layer of mannoproteins, which has previously been described as a molecular shield to protect the highly immunogenic glucan from the innate immune system, adaptation to environmental signals results in exposure of the glucan and chitin network, making it accessible to immune cells (Sherrington et al., 2017)