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The hydrodynamic diameters of the samples were measured by dynamic light scattering (DLS) on Malvern Zetasizer Ultra
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Studies indicate that the lifetime risk of CRC in individuals with PMS2 mutations ranges between 10% and 20%, significantly lower than that of MLH1, MSH2, and MSH6 mutation carriers ( PMS2 carriers is estimated to be between 12% and 15%, also lower than those associated with other MMR genes
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