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A deficiency in carnitine can therefore lead to a decline in these important processes, which can result in a variety of symptoms

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In contrast, the transport of glycolytic substrates such as lactate from oligodendrocytes to neurons is found to be disrupted in SOD1 G93A mice spinal cord (Lee et al., 2012

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3 The clinical onset of metabolic mediated neurodegenerative disease Given the ability of DM to lead to aging processes tied to oxidative stress, neuronal and vascular injury, mitochondrial dysfunction, stem cell loss, and immune system disorders, it becomes evident that loss of metabolic homeostasis with DM can result in multiple neurodegenerative disorders