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343,1075 Supplementing with pyruvate, a key link between glycolysis and the TCA cycle, improves brain energy status

Mechanistically, the promotion of K63 ubiquitination on liver kinase B1 (Lkb1) facilitated Lkb1-Strad-Mo25 complex formation and activated Lkb1 upstream of AMPK, which then promoted FAO (153)

Behavioural and Emotional Regulation: Challenging behaviours such as meltdowns, self-injurious behaviour, aggression or extreme rigidity are often the result of unmet communication needs, sensory overload, anxiety, or an inability to regulate overwhelming emotions

NAD+ and CoQ10 are also given IV

The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes