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Minimizing side effects Several strategies reduce the likelihood and severity of side effects: Start low and titrate up

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When implanted subcutaneously on the dorsal surface of nude mice, this scaffold exhibited IVD-like changes, with a core area predominantly expressing collagen II and glycosaminoglycans and a peripheral area showing significant deposition of collagen I

Multiple pathomolecular processes contribute to neuroinflammation, oligodendrocyte cell death, and progressive neuronal dysfunction