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Zhang CY, Lin W, Gao J, Shi X, Davaritouchaee M, Nielsen AE, Mancini RJ, Wang Z

Some patients treated with methionine or SAMe may not respond if SAH is elevated or if methylation is blocked by toxic burden, inflammation, gut dysfunction, medication effects, kidney or liver clearance issues, diet, hydration, sleep, or lifestyle factors

Abstract The senescence of nucleus pulposus (NP) cells (NPCs), which is induced by the anomalous accumulation of reactive oxygen species (ROS), is a major cause of intervertebral disc degeneration (IVDD)

Both the YE and R5 LSC subtypes reduced liver injury markers and improved immune balance, with the less mature YE cells exhibiting the greatest efficacy ( Table 2 )